a public research recordlast updated 11 September 2026
Data

Twelve files, one archive identifier, CC BY 4.0.

Everything every paper rests on, deposited together at 10.5281/zenodo.21799233. That identifier is what every data availability statement points at.

FileFormatSize
ABE_GUIDE_TABLE.csvEvery base editor guide considered at this position, scoredcsv1.2 kB
ABE_OFFTARGET_SUMMARY.csvOff target counts before and after the editability filtercsv1.3 kB
ABE_ACCESSIBILITY_TOPGENES.csvWhere the surviving off target sites sit, by genecsv570 B
ABE_RESCUE_MODEL.csvCorrection efficiency against recovered currentcsv330 B
PE_VS_ABE_EFFICIENCY.csvPublished correction rates for both editors, in heart and in dishcsv2.0 kB
MODALITY_COMPARISON.csvEvery therapeutic modality considered, with its blockercsv2.3 kB
NTD_FUNCTIONAL_EVIDENCE_TABLE.csvEvery measured variant in this domain, with its source identifiercsv6.9 kB
CLINVAR_ACCESS_ROUTES.csvEach surveyed tool, and how it reaches the databasecsv744 B
SCN5A_SPLICING_SUMMARY.csvThe discarded message measurement, heart against braincsv447 B
SCN5A_TRANSCRIPTS.csvThe transcripts the measurement was taken acrosscsv1.0 kB
UPREGULATION_HEADROOM.csvThe 0.0045 percent reserve, and the 1.5 fold the route neededcsv154 B
CORRECTIONS_20260806.mdEvery number changed on 6 August 2026, with the reasonmd4.9 kB

What the archive does not hold

Four papers named derived tables as deposited that the archive does not contain, and an audit on 6 August 2026 found the same defect in six of eleven documents. A reader can catch a wrong number by recomputing it, and cannot catch a false statement about what an archive holds without downloading it and finding nothing there. That is why the audit is published rather than quietly fixed. Nothing has been re-uploaded and no record has a version 2, because a deposit is a deliberate act rather than a side effect of a website update.

Staged molecular dynamics datasets (September 2026)

A 1.41-million-atom all-atom simulation was constructed to test whether R104Q physically collapses the selectivity filter. The production run completed its first nanosecond of sampling on an RTX 4060 Ti GPU, confirming an open DEKA filter radius (5.30 angstroms) and continuous 12.8-water hydration column. The full trajectory arrays, coordinate snapshots, and analysis checkpoints are staged on the compute workstation for formal Zenodo deposition upon completion of the 40-block gold standard protocol.

FileFormatStatus
gfp_trajectory_dataset.json20-block trajectory time series: DEKA radius, hydration, RMSD, staple distancejsonStaged
SUMMARY_TABLE.mdTabulated trajectory statistics across 1.004 nanoseconds of production dynamicsmdStaged
checkpoint_step_00502000/OpenMM binary state, box vectors, and velocities at Milestone 2bin/xmlStaged
Visual atlas and 3D structural viewer The three costed experimental protocols